Lipid A and Related Compounds. XXIX. Synthesis of Biologically Active N-Acylated L-Asparagine-Containing D-Glucosamine Derivatives Structurally Related to Lipid A

Yoshitomo SUHARA; Misa ARAKAWA; Kiyoshi IKEDDA; Kazuo ACHIWA

doi:10.1248/cpb.42.2526

Yoshitomo SUHARA, Misa ARAKAWA, Kiyoshi IKEDDA, Kazuo ACHIWA

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Keywords: D-glucosamine-asparagine compound, N-acylated L-aspartic acid, lipid A analog, glucosylamine, mitogenic activity, nitric oxide productivity

JOURNAL FREE ACCESS

1994 Volume 42 Issue 12 Pages 2526-2531

DOI https://doi.org/10.1248/cpb.42.2526

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Abstract

New β-N-acylated L-asparagine-linked D-glucosamine derivatives, in which the reducing unit of lipid A has been mimicked by a lipoamino acid, have been synthesized. Compounds 1 and 2 exhibit mitogenicity and nitric oxide (NO) productivity.

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