Synthesis and Human Immunodeficiency Virus (HIV)-1 Protease Inhibitory Activity of Tripeptide Analogues Containing a Dioxoethylene Moiety

Tomoyuki KITAZAKI; Tsuneo ASANO; Koichi KATO; Shoji KISHIMOTO; Katsumi ITOH

doi:10.1248/cpb.42.2636

北崎智幸, 浅野常夫, 加藤光一, 岸本彰二, 伊藤克己

著者情報

キーワード: human immunodeficiency virus (HIV) protease inhibitor, tripeptide analogue, dioxoethylene isostere, transition state mimic, HIV protease inhibitory activity

ジャーナルフリー

1994 年 42 巻 12 号 p. 2636-2640

DOI https://doi.org/10.1248/cpb.42.2636

詳細

抄録

Tripeptide analogues 2 and 3 containing a dioxoethylene moiety were designed based on the characteristic structure of the naturally occurring human immunodeficiency virus (HIV)-1 protease inhibitors RPI-856 A, B, C and D (1). The compounds (2, 3) prepared showed high inhibitory activity, comparable to that of RPI-856 A, against HIV-1 protease in vitro.

責任著者(Corresponding author)

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