Synthesis of 3-Chloropyridazine-6-carboxylic Acid Hydrazide and Selective Hydrazinolysis of 3, 6-Substituted Pyridazines

Muneo MORISHITA; Jun KOBAYASHI; Hiroshi YAMADA; Takehiko YAJIMA

doi:10.1248/cpb.42.371

Muneo MORISHITA, Jun KOBAYASHI, Hiroshi YAMADA, Takehiko YAJIMA

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Keywords: 3-chloropyridazine-6-carboxylic acid hydrazide, synthesis, hydrazinolysis, pyridazine derivative, chelating agent

JOURNAL FREE ACCESS

1994 Volume 42 Issue 2 Pages 371-372

DOI https://doi.org/10.1248/cpb.42.371

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Abstract

3-Chloropyridazine-6-carboxylic acid hydrazide (5) was synthesized by employing hydrazine monohydrate and methyl levulinate as starting materials through five steps, including hydrozinolysis. Selective hydrazinolysis of 3, 6-substituted pyridazines was investigated.

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