SYNTHESIS AND MUTAGENICITY OF A NEW MUTAGEN, 2-AMINO-1, 7, 9-TRIMETHYLIMIDAZO-[4, 5-g]QUINOXALINE, AND ITS ANALOG
1994 年 42 巻 2 号 p. 408-409
詳細
1994 年 42 巻 2 号 p. 408-409
A new mutagen, 2-amino-1, 7, 9-trimethylimidazo[4, 5-g]quinoxaline (1), isolated from beef extract, was synthesized from 3-fluoro-2-methylaniline via an intermediate, 2, 8-dimethyl-7-methylaminoquinoxaline (7a). Its 2-methylanalog (2) was also synthesized from the same intermediate. The synthetic 1 showed the same mutagenic activity as the isolated mutagen. However, 2 was non-mutagenic.
