Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
EFFECT OF ALKYL CHAIN LENGTH OF CONSTITUENT FATTY ACID (FA) ON THE THERMO-SENSITIVITY OF FA-NICOTINAMIDE CRYSTALLINE COMPLEX
Shoko YOKOYAMA, Youko MIYAMURA, Tadao FUJIE
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Keywords: thermo-sensitive complex, fatty acid, alkyl chain length, thermo-responsive release, drug delivery system
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1994 Volume 42 Issue 2 Pages 422-424

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Abstract
Thermo-sensitive fatty acid (FA)-nicotinamide (NAA) crystalline complexes, FA-NAA, were prepared, and the release of NAA from FA-NAA was investigated in an aqueous medium. The response-temperature of FA-NAA to release NAA was reduced as the carbon number of the constituent FA decreased.
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© The Pharmaceutical Society of Japan
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