Synthesis of 4-Alkoxyaryl β-D-Glucopyranosides and Their Inhibitory Effects on Histamine Release from Rat Peritoneal Mast Cells Induced by Concanavalin A

Tzer Chuan WANG; Haruhiro FURUKAWA; Yasunori NIHRO; Hisao KAKEGAWA; Hitoshi MATSUMOTO; Toshio SATOH

doi:10.1248/cpb.42.570

Tzer Chuan WANG, Haruhiro FURUKAWA, Yasunori NIHRO, Hisao KAKEGAWA, Hitoshi MATSUMOTO, Toshio SATOH

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Keywords: 4-alkoxyaryl β-D-glucopyranoside, 4-decyloxy-2, 3, 6-trimethylphenyl β-D-glucopyranoside, histamine release inhibition, β-glucosidase

JOURNAL FREE ACCESS

1994 Volume 42 Issue 3 Pages 570-575

DOI https://doi.org/10.1248/cpb.42.570

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Abstract

The inhibitory effects of newly synthesized 4-alkoxyaryl β-D-glucopyranosides on histamine release from rat peritoneal mast cells induced by concanavalin A were examined. A plot of hydrophobicity (k') against inhibitory activity of the compounds showed a distinct maximum, and 4-decyloxy-2, 3, 6-trimethylphenyl β-D-glucopyranoside was the most potent inhibitor among the tested compounds.

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