New Steroidal Saponins from the Bulbs of Allium giganteum Exhibiting Potent Inhibition of cAMP Phosphodiesterase Activity

Yoshihiro MIMAKI; Tamotsu NIKAIDO; Katsumi MATSUMOTO; Yutaka SASHIDA; Taichi OHMOTO

doi:10.1248/cpb.42.710

三巻祥浩, 二階堂保, 松本勝己, 指田豊, 大本太一

著者情報

キーワード: Allium giganteum, Liliaceae, steroidal saponin, spirostanol saponin, furostanol saponin, cAMP phosphodiesterase inhibition

ジャーナルフリー

1994 年 42 巻 3 号 p. 710-714

DOI https://doi.org/10.1248/cpb.42.710

詳細

抄録

A new spirostanol saponin and two new furostanol saponins were isolated from the fresh bulbs of Allium giganteum together with several known saponins. The structures of the new compounds were determined on the basis of spectroscopic data, the products formed on hydrolysis and by comparing their properties with those of known compounds. The isolated saponins and their derivatives were evaluated for inhibitory activity by examining their action on cAMP phosphodiesterase as a primary screening test to identify new medicinal agents.

責任著者(Corresponding author)

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