INHIBITORY EFFECTS OF (4-ALKOXY-2, 3, 6-TRIMETHYLPHENYL) GLYCOPYRANOSIDES ON HISTAMINE RELEASE INDUCED BY ANTIGEN-ANTIBODY REACTION

Tzer Chuan WANG; Hisao KAKEGAWA; Shigeru NAKAISHI; Hitoshi MATSUMOTO; Toshio SATOH

doi:10.1248/cpb.42.1002

王澤川, 掛川寿夫, 名賀石繁, 松本仁, 佐藤利夫

著者情報

キーワード: histamine release, histamine release inhibition, antigen-antibody reaction, 4-alkoxy-2, 3, 6-trimethylphenyl glycopyranoside, 4-hexoxy-2, 3, 6-trimethylphenyl α-D-mannopyranoside

ジャーナルフリー

1994 年 42 巻 4 号 p. 1002-1004

DOI https://doi.org/10.1248/cpb.42.1002

詳細

抄録

The inhibitory effects of newely synthesized 4-alkoxy-2, 3, 6-trimethylphenyl D-glycopyranosides on histamine release induced by antigen-antibody reaction were examined. Among the compounds tested, 4-hexoxy-2, 3, 6-trimethylphenyl α-D-mannopyranoside exhibited the strongest inhibitory effect. Furthermore, 4-hexoxy-2, 3, 6-trimethylphenyl α-D-glucopyranoside and α-D-galactopyranoside markedly inhibited antigen-induced histamine release, and their activities were more potent than those of the corresponding β-anomers. These results suggest that these compounds may possess excellent anti-allergic activities.

責任著者(Corresponding author)

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