Crystal Structures of Nadifloxacin Anhydride and Its Hemihydrate

Abstract

The crystal structures of nadifloxacin [9-fluoro-6, 7-dihydro-8-(4-hydroxy-1-piperidyl)-5-methyl-1-oxo-1H, 5H-benzo[i, j]quinolizine-2-carboxylic acid, OPC-7251]anhydride and its hemihydrate were determined by X-ray analysis. In both crystals, two crystallographically independent molecules (A and B) are contained in an asymmetric unit. Two of molecule A and two of molecule B are tightly bound by hydrogen bonds around a center of symmetry. The structural features of nadifloxacin molecules in the two crystals are very similar to each other.