Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
A NOVEL METHOD FOR THE PREPARATION OF CONTROLLED-RELEASE THEOPHYLLINE CAPSULES COATED WITH A POLYELECTROLYTE COMPLEX OF K-CARRAGEENAN AND CHITOSAN
Hisao TOMIDA, Chie NAKAMURA, Setsuo KIRYU
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Keywords: polyelectrolyte complex membrane capsule, theophylline, controlled-release, κ-carrageenan, chitosan, drug delivery system
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1994 Volume 42 Issue 4 Pages 979-981

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Abstract
A novel method for the preparation of κ-carrageenan/chitosan polyelectrolyte complex (PEC) membrane capsules containing theophylline as a model drug was developed. The theophylline release from the capsules followed zero-order kinetics, and the release rates were independent of pH of the dissolution medium, suggesting that κ-carrageenan/chitosan PEC capsules could be a useful vehicle for controlled-release drug delivery.
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© The Pharmaceutical Society of Japan
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