Non-stereoselective Formation of 3α, 7α, 12α, 24-Tetrahydroxy-5β-cholestan-26-oic Acid during Cholic Acid Biosynthesis

Noriko KOBAYASHI; Chiaki HAGIWARA; Masuo MORISAKI; Masatoshi YURI; Izumi OYA; Yoshinori FUJIMOTO

doi:10.1248/cpb.42.1028

著者情報

キーワード: bile acid, cholic acid, β-oxidation, 3α, 7α, 12α-trihydroxy-5β-cholestan-26-oic acid, 3α, 7α, 12α, 24-tetrahydroxy-5β-cholestan-26-oic acid, 3α, 7α, 12α-trihydroxy-5β-cholest-24-en-26-oic acid

ジャーナルフリー

1994 年 42 巻 5 号 p. 1028-1035

DOI https://doi.org/10.1248/cpb.42.1028

詳細

抄録

Incubation of (25RS)-, (25R)- and (25S)-3α, 7α, 12α-trihydroxy-5β-cholestan-26-oic acid (THCA, 6, 6a, 6b) and (24E)-3α, 7α, 12α-trihydroxy-5β-cholest-24-en-26-oic acid (7) with rat liver mitochondria gave all four stereoisomers (9a, 9b, 9c, 9d) of 3α, 7α, 12α, 24-Tetrahydroxy-5β-cholestan-26-oic acid (TeHCA). The corresponding 27-nor analogs (10, 11) were also converted non-stereoselectively to a 1 : 1 mixture of the epimeric 24-hydroxy compounds (12).

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