ESCINS-Ia, Ib, IIa, IIb, AND IIIa, BIOACTIVE TRITERPENE OLIGOGLYCOSIDES FROM THE SEEDS OF AESCULUS HIPPOCASTANUM L. : THEIR INHIBITORY EFFECTS ON ETHANOL ABSORPTION AND HYPOGLYCEMIC ACTIVITY ON GLUCOSE TOLERANCE TEST

Masayuki YOSHIKAWA; Emiko HARADA; Toshiyuki MURAKAMI; Hisashi MATSUDA; Noriko WARIISHI; Johji YAMAHARA; Nobutoshi MURAKAMI; Isao KITAGAWA

doi:10.1248/cpb.42.1357

Masayuki YOSHIKAWA, Emiko HARADA, Toshiyuki MURAKAMI, Hisashi MATSUDA, Noriko WARIISHI, Johji YAMAHARA, Nobutoshi MURAKAMI, Isao KITAGAWA

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Keywords: escin IIa, escin IIb, Aesculus hipocastanum, ethanol absorption inhibitor, hypoglycemic activity, oral glucose tolerance test

JOURNAL FREE ACCESS

1994 Volume 42 Issue 6 Pages 1357-1359

DOI https://doi.org/10.1248/cpb.42.1357

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Abstract

Five triterpene oligoglycosides named escins-Ia, Ib, IIa, IIb, and IIIa were isolated from the seeds of Aesculus hippocastanum L. and their chemical structures were determined on the basis of chemical and physicochemical evidence. Escins-Ia, Ib, IIa, and IIb were found to exhibit inhibitory effect on ethanol absorption and hypoglycemic activity on oral glucose tolerance test in rats. Among them, escins-IIa and IIb showed the higher activities for both bioassay, while desacylescins-I and II had no activity.

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