ESCINS-Ia, Ib, IIa, IIb, AND IIIa, BIOACTIVE TRITERPENE OLIGOGLYCOSIDES FROM THE SEEDS OF AESCULUS HIPPOCASTANUM L. : THEIR INHIBITORY EFFECTS ON ETHANOL ABSORPTION AND HYPOGLYCEMIC ACTIVITY ON GLUCOSE TOLERANCE TEST

Masayuki YOSHIKAWA; Emiko HARADA; Toshiyuki MURAKAMI; Hisashi MATSUDA; Noriko WARIISHI; Johji YAMAHARA; Nobutoshi MURAKAMI; Isao KITAGAWA

doi:10.1248/cpb.42.1357

吉川雅之, 原田英美子, 村上敏之, 松田久司, 割石紀子, 山原條二, 村上啓寿, 北川勲

著者情報

キーワード: escin IIa, escin IIb, Aesculus hipocastanum, ethanol absorption inhibitor, hypoglycemic activity, oral glucose tolerance test

ジャーナルフリー

1994 年 42 巻 6 号 p. 1357-1359

DOI https://doi.org/10.1248/cpb.42.1357

詳細

抄録

Five triterpene oligoglycosides named escins-Ia, Ib, IIa, IIb, and IIIa were isolated from the seeds of Aesculus hippocastanum L. and their chemical structures were determined on the basis of chemical and physicochemical evidence. Escins-Ia, Ib, IIa, and IIb were found to exhibit inhibitory effect on ethanol absorption and hypoglycemic activity on oral glucose tolerance test in rats. Among them, escins-IIa and IIb showed the higher activities for both bioassay, while desacylescins-I and II had no activity.

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