ABSOLUTE STEREOSTRUCTURES OF HYDRAMACROSIDES A AND B, NEW BIOACTIVE SECOIRIDOID GLUCOSIDE COMPLEXES FROM THE LEAVES OF HYDRANGEA MACROPHYLLA SERINGE VAR. THUNBERGII MAKINO

Masayuki YOSHIKAWA; Tomohiko UEDA; Hisashi MATSUDA; Johji YAMAHARA; Nobutoshi MURAKAMI

doi:10.1248/cpb.42.1691

Masayuki YOSHIKAWA, Tomohiko UEDA, Hisashi MATSUDA, Johji YAMAHARA, Nobutoshi MURAKAMI

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Keywords: hydramacroside A, hydramacroside B, secoiridoid glucoside complex, Hydrangea macrophylla var. thunbergii, ^<13>C NMR glycosylation shift, histamine release inhibitator

JOURNAL FREE ACCESS

1994 Volume 42 Issue 8 Pages 1691-1693

DOI https://doi.org/10.1248/cpb.42.1691

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Abstract

Two new bioactive secoiridoid glucoside complexes named hydramacrosides A and B were isolated from the leaves of Hydrangea macrophylla SERINGE var. thunber gii MAKINO. The absolute stereostructures of hydramacrosides A and B were elucidated on the basis of chemical and physicochemical evidence which included the application of the ¹³C NMR glycosylation shift rule of 1, 1'-disaccharides and the modified Mosher's method. Hydramacrosides A and B exhibited inhibitory effect on the histamine release from rat mast cells induced by antigen-antibody reaction.

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