Preparation of 2, 2-Disubstituted 2, 3-Dihydro-3-phenyl-1, 3, 4-thiadiazoles

Abstract

Reaction of N'-phenylthioformohydrazide with ketones in the presence of trimethylsilyl chloride proceeded easily to afford the corresponding 2, 2-disubstituted 2, 3-dihydro-3-phenyl-1, 3, 4-thiadiazoles in good yields.