Improved Procedure for N-Formylation of Amines to Formamides Using Formic Acid, Oxalyl Chloride and Imidazole

Tokujiro KITAGAWA; Junko ITO; Chinatsu TSUTSUI

doi:10.1248/cpb.42.1931

北川徳治郎, 伊藤淳子, 筒井千夏

著者情報

キーワード: formylation, N-formylimidazole, imidazole, formamide, N, N'-carbonyldiimidazole, oxalyl chloride

ジャーナルフリー

1994 年 42 巻 9 号 p. 1931-1934

DOI https://doi.org/10.1248/cpb.42.1931

詳細

抄録

The reaction of imidazole (15) with formyl chloride (14), generated in situ by the action of oxalyl chloride (10) on formic acid (3), afforded N-formylimidazole (7), which is a convenient formylating reagent. This procedure was used to prepare N-formyl derivatives (2) of aliphatic, aromatic and heteroaromatic amines (1) under mild conditions.

責任著者(Corresponding author)

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