J-STAGE Home  >  Publications - Top  > Bibliographic Information

Chemical and Pharmaceutical Bulletin
Vol. 43 (1995) No. 10 P 1706-1718

Language:

http://doi.org/10.1248/cpb.43.1706


Dolastatin 10 (1) is a potent antineoplastic pentapeptide. Novel dolastatin 10 analogs each modified at one of the constituent amino acid derivatives, were synthesized and their antitumor activity was evaluated against P388 leukemia in mice. The structural requirements for antitumor activity are discussed. Some of the analogs, 31c, 35c, 38b, and 50c showed excellent activity in vivo. Highly active 50c, which lacks the thiazole group of 1, was selected for further development as an antitumor agent.

Copyright © The Pharmaceutical Society of Japan

Article Tools

Share this Article