Transformation of 1, 4-Dihydropyridine Ring of Calcium Antagonist NZ-105 into Cyclohexenone Ring

Yoshimasa KAMIKAWAJI; Ryozo SAKODA; Kiyotomo SETO

doi:10.1248/cpb.43.315

上川路益昌, 迫田良三, 瀬戸浄智

著者情報

キーワード: calcium antagonist, 1, 4-dihydropyridine, cyclohexenonephosphonate, ^<13>C-labeling, hydrolysis

ジャーナルフリー

1995 年 43 巻 2 号 p. 315-317

DOI https://doi.org/10.1248/cpb.43.315

詳細

抄録

On hydrolysis of the calcium antagonist, 2-(N-benzyl-N-phenylamino)ethyl 5-(5, 5-dimethyl-2-oxo-1, 3, 2-dioxaphosphorinan-2-yl)-1, 4-dihydro-2, 6-dimethyl-4-(3-nitrophenyl)pyridine-3-carboxylate hydrochloride ethanol (NZ-105 1·HCl·EtOH) in 35% hydrochloric acid, the 1, 4-dihydropyridine ring was transformed to a cyclohexeone ring, affording the cyclohexenonephosphonates 2 and 3.

責任著者(Corresponding author)

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