Disaccharides as Endomannosidase Inhibitors : Syntheses of α-Homomannojirimycin and β-Homomannojirimycin Linked to D-Glucose and D-Mannose

Yoshitomo SUHARA; Kazuo ACHIWA

doi:10.1248/cpb.43.414

Yoshitomo SUHARA, Kazuo ACHIWA

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Keywords: endomannosidase inhibitor, deoxynojirimycin, α-homomannojirimycin, β-homomannojirimycin, N-linked glycoprotein, anti human immunodeficiency activity

JOURNAL FREE ACCESS

1995 Volume 43 Issue 3 Pages 414-420

DOI https://doi.org/10.1248/cpb.43.414

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Abstract

4-O-(α-D-Glucopyranosyl)-αHMJ (Glcα1, 4HMJ), 4-O-(α-mannopyranosyl)-αHMJ (Manα1, 4αHMJ), 4-O-(α-glucopyranosyl)-βHMJ (Glcα1, 4βHMJ), and 4-O-(α-mannopyranosyl)-βHMJ (Manα1, 4βHMJ) were synthesized as endomannosidase inhibitors which are potentially useful both for probing the pathways of N-linked glycoprotein processing and for the chemotherapy of some viral diseases.

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