Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
Stability of a 1β-Methylcarbapenem Antibiotic, Meropenem (SM-7338) in Aqueous Solution
Yutaka TAKEUCHIMakoto SUNAGAWAYutaka ISOBEYukari HAMAZUMETetsuo NOGUCHI
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1995 Volume 43 Issue 4 Pages 689-692

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Abstract

The stability and the degradation products of 1β-methylcarbapenem, meropenem in aqueous solution were investigated. In pH 4-8 dilute solution pseudo-first-order degradation was observed, and good stability of meropenem in aqueous solution was demonstrated by the effect of 1β-methyl group against hydrolysis of β-lactam ring. As degradation products, the β-lactam hydrolyzed product and the dimer product resulting from intermolecular aminolysis of β-lactam ring by the amine of the second molecule were described.

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© The Pharmaceutical Society of Japan
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