Diastereoselective Addition of Chiral Aliphatic Imines and 2-Alkyl-1, 3-oxazolidines to Organometallic Reagents

Abstract

The reaction of organocerium reagents with chiral aliphatic imines derived from (R)-O-methylphenylglycinol afforded the corresponding amines with high diastereoselectivity. In contrast, the reaction of Grignard reagents with chiral 2-alkyl-1, 3-oxazolidines derived from (R)-N-methylphenylglycinol afforded the amines with changeover in diastereoselectivity.