Synthesis and Pharmacological Evaluation of 1, 2, 3, 4-Tetrahydro-β-carboline Derivatives

Yutaka KAWASHIMA; Akiyo HORIGUCHI; Minoru TAGUCHI; Yoshimi TUYUKI; Yasuko KARASAWA; Hiroaki ARAKI; Katsuo HATAYAMA

doi:10.1248/cpb.43.783

Yutaka KAWASHIMA, Akiyo HORIGUCHI, Minoru TAGUCHI, Yoshimi TUYUKI, Yasuko KARASAWA, Hiroaki ARAKI, Katsuo HATAYAMA

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Keywords: 1, 2, 3, 4-tetrahydro-β-carboline, lipid peroxidation, potassium cyanide intoxication, structure-activity relationship

JOURNAL FREE ACCESS

1995 Volume 43 Issue 5 Pages 783-787

DOI https://doi.org/10.1248/cpb.43.783

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Abstract

A series of 1, 2, 3, 4-tetrahydro-β-carbolines has been synthesized and evaluated for cerebral protecting effects against lipid peroxidation and potassium cyanide intoxication in mice. Most of the compounds synthesized had potent effects against lipid peroxidation. Among them, 1-(3, 5-dimethoxyphenyl)-2-propyl-1, 2, 3, 4-tetrahydro-β-carboline (22) was found to have a combination of potent effects against both lipid peroxidation and potassium cyanide intoxication. Structure-activity relationships are discussed.

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