Studies on Metabolites of Mycoparasitic Fungi. III. New Sesquiterpene Alcohol from Trichoderma koningii

Abstract

A new sesquiterpene alcohol, named tricho-acorenol (1), was isolated from the culture broth of Trichoderma koningii OUDEMANS along with methyl benzoate (2), cyclonerodiol (3), cyclo-(L-Pro-L-Leu) (4), 4-hydroxyphenethyl alcohol (5), uracil (7), and a ceramide (6). The ceramide (6) was identified as (2S, 3S, 4R)-2-[(2R)-2-hydroxytetracosanoylamino]-1, 3, 4-octadecanetriol by the use of ion-spray ionization MS (ISI-MS) and comparison of the optical rotation and the ¹H-NMR data with those of (2S, 3S, 4R)-2-[(2R)-2-hydroxytetracosanoylamino]-1, 3, 4-hexadecanetriol. The structure of tricho-acorenol was elucidated to be (1S, 4S, 5S, 7R)-1-isopropyl-4, 8-dimethyl-spiro-[4.5]dec-8-en-7-ol on the basis of chemical and spectroscopic evidence.