Studies on New Phosphodiesterase Inhibitors. I. Synthesis of 1-(2, 3-Epoxypropoxy)-2(4)-fluorobenzenes and 1-(2-Hydroxy-3-morpholinopropoxy and Piperazino) fluorobenzene Derivatives

Abstract

A series of 1-(2, 3-epoxypropoxy)-2(4)-fluorobenzenes and their corresponding 1-(2-hydroxy-3-morpholino propoxy and piperazino)fluorobenzene derivatives (8a-f) were synthesised via a short synthetic route in good chemical yields and were evaluated for intropic and chronotropic activity in isolated guinea-pig atria preparation. The compounds act as potential phosphodiesterase (PDE) inhibitors with desirable biological activity and have considerable promise in heart therapy.