Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
TOTAL SYNTHESIS OF NATURAL(+)-DUOCARMYCIN SA
Hideaki MURATAKE, Naoshige MATSUMURA, Mitsutaka NATSUME
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Keywords: duocarmycin SA, antitumor antibiotic, total synthesis, indole formation reaction
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1995 Volume 43 Issue 6 Pages 1064-1066

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Abstract
A total synthesis of natural (+)-duocarmycin SA (1) was achieved as shown in Chart 1, starting from L-malic acid (5) by using a Lewis acid-mediated indole formation reaction of a pyrrole precursor 14 to form the key compound 15.
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© The Pharmaceutical Society of Japan
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