Scale-Up of Agitation Fluidized Bed Granulation. II. Effects of Scale, Air Flow Velocity and Agitator Rotational Speed on Granule Size, Size Distribution, Density and Shape

Satoru WATANO; Yoshinobu SATO; Kei MIYANAMI; Takayuki MURAKAMI; Nobumasa NAGAMI; Yoshihiro ITO; Tetsuro KAMATA; Nobuhito ODA

doi:10.1248/cpb.43.1217

Satoru WATANO, Yoshinobu SATO, Kei MIYANAMI, Takayuki MURAKAMI, Nobumasa NAGAMI, Yoshihiro ITO, Tetsuro KAMATA, Nobuhito ODA

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Keywords: scale-up, granulation, agitation fluidized bed, scale factor, operating variable, granule property

JOURNAL FREE ACCESS

1995 Volume 43 Issue 7 Pages 1217-1220

DOI https://doi.org/10.1248/cpb.43.1217

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Abstract

Scale-up characteristics of agitation fluidized bed granulation using a pharmaceutical standard formulation was described. The effects of scale, air flow velocity and agitator rotational speed on granule properties such as granule mass median size, size distribution, apparent density and shape factor were investigated experimentally. Based on the results obtained, the effects of these parameters on granule growth and the mechanism of granule formation in different sized equipment were discussed.

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