Scale-Up of Agitation Fluidized Bed Granulation. II. Effects of Scale, Air Flow Velocity and Agitator Rotational Speed on Granule Size, Size Distribution, Density and Shape

Satoru WATANO; Yoshinobu SATO; Kei MIYANAMI; Takayuki MURAKAMI; Nobumasa NAGAMI; Yoshihiro ITO; Tetsuro KAMATA; Nobuhito ODA

doi:10.1248/cpb.43.1217

綿野哲, 佐藤嘉信, 宮南啓, 村上孝之, 永見信正, 伊藤義弘, 釜田哲郎, 小田宣人

著者情報

キーワード: scale-up, granulation, agitation fluidized bed, scale factor, operating variable, granule property

ジャーナルフリー

1995 年 43 巻 7 号 p. 1217-1220

DOI https://doi.org/10.1248/cpb.43.1217

詳細

抄録

Scale-up characteristics of agitation fluidized bed granulation using a pharmaceutical standard formulation was described. The effects of scale, air flow velocity and agitator rotational speed on granule properties such as granule mass median size, size distribution, apparent density and shape factor were investigated experimentally. Based on the results obtained, the effects of these parameters on granule growth and the mechanism of granule formation in different sized equipment were discussed.

責任著者(Corresponding author)

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