Scale-Up of Agitation Fluidized Bed Granulation. III. Effects of Powder Feed Weight and Blade Angle on Granule Size, Density and Shape

Abstract

This paper presents the experimental results of a study on the scale-up characteristics of granule comopaction and sphericity in an agitation fluidized bed granulation. A pharmaceutical standard formulation was granulated using agitation fluidized bed of three sizes (vessel diameter : 125, 230, 500 mm). The effects of powder feed weight and agitator blade angle on the granule properties of size, density and shape were studied. It was found that granules were compressed and made spherical with an increase in agitator blade angle and vessel scale, while they were not influenced by the powder feed ratio.