Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Total Synthesis of Nortopsentins A-D, Marine Alkaloids
Ikuo KAWASAKI, Masayuki YAMASHITA, Shunsaku OHTA
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Keywords: imidazole, marine alkaloid, Suzuki reaction, palladium catalyst, arylboronic acid, nortopsentin
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1996 Volume 44 Issue 10 Pages 1831-1839

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Abstract
Nortopsentins A-D, antifungal 1, 4-bisindolylimidazole marine alkaloids isolated from a sponge, were synthesized through palladium-catalyzed cross-coupling of 3-indolylboronic and 6-bromo-3-indolylboronic acids with halogenoimidazoles as the key reaction.
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© The Pharmaceutical Society of Japan
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