Bioactive Saponins and Glycosides. V. Acylated Polyhydroxyolean-12-ene Triterpene Oligoglycosides, Camelliasaponins A₁, A₂, B₁, B₂, C₁, and C₂, from the Seeds of Camellia japonica L. : Structures and Inhibitory Activity on Alcohol Absorption

抄録

Acylated polyhydroxyolean-12-ene triterpene oligoglycosides, camelliasaponins A₁, A₂, B₁, B₂, C₁, and C₂, were isolated from the seeds of Camellia japonica L. The structures of six camelliasaponins were elucidated on the basis of chemical and physicochemical evidence. Camelliasaponins B₁, B₂, C₁, and C₂ were found to exhibit inhibitory activity on ethanol absorption. By comparison of the inhibitory activities for camelliasaponins with those for desacyl-camelliasaponins, acyl groups such as the angeloyl or tigloyl group were found to be essential to exerting the activity.