Lipid A and Related Compounds. XXX. Synthesis of Biologically Active N, N'-Diacyl Chitobiose Derivatives Structurally Related to Lipid A

Kiyoshi IKEDA; Keisuke MIYAJIMA; Kazuo ACHIWA

doi:10.1248/cpb.44.1958

Lipid A and Related Compounds. XXX. Synthesis of Biologically Active N, N'-Diacyl Chitobiose Derivatives Structurally Related to Lipid A

Kiyoshi IKEDA, Keisuke MIYAJIMA, Kazuo ACHIWA

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Keywords: N-acylated glycolipid, N, N', -diaclychitobiose, lipid A analogue, mitogenic activity, NO production

JOURNAL FREE ACCESS

1996 Volume 44 Issue 10 Pages 1958-1961

DOI https://doi.org/10.1248/cpb.44.1958

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Abstract

Two new glycolipids, which mimic lipid A disaccharide, were synthesized from N, N'-diacylchitobiose via a key intermediate (2). They showed mitogenicity and nitric oxide (NO) productivity.

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