Studies on Novel and Chiral 1, 4-Dihydropyridines. I. Synthesis and Conformational Analysis of Novel NADH Model Compounds, N-Substituted (S)-3-(p-Tolylsulfinyl)-1, 4-dihydropyridines

Takeshi IMANISHI; Satoshi OBIKA; Toshihiko NISHIYAMA; Masahiro NISHIMOTO; Yoshimitsu HAMANO; Kazuyuki MIYASHITA; Chuzo IWATA

doi:10.1248/cpb.44.267

Takeshi IMANISHI, Satoshi OBIKA, Toshihiko NISHIYAMA, Masahiro NISHIMOTO, Yoshimitsu HAMANO, Kazuyuki MIYASHITA, Chuzo IWATA

Author information

Keywords: NADH model, 1, 4-dihydropyridine, chiral p-tolylsulfinyl group, conformational analysis, ^1H-NMR, X-ray analysis

JOURNAL FREE ACCESS

1996 Volume 44 Issue 2 Pages 267-272

DOI https://doi.org/10.1248/cpb.44.267

Details

Abstract

Novel NADH model compounds, (S_S)-1-alkyl-3-(p-tolylsulfinyl)-1, 4-dihydropyridines (2) and (R_S)-1-benzyl-3-[1-oxo-2-(p-tolylsulfinyl)ethyl]-1, 4-dihydropyridine (3), were synthesized. ¹H-NMR study and X-ray analysis of 2 revealed its preferred conformation.

Corresponding author

Register with J-STAGE for free!