Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
SYNTHESIS OF 1, 4-DIKETONES BY MICHAEL ADDITION OF O-AROYLMANDELO-NITRILES INVOLVING REARRANGEMENT OF AROYL GROUP AND DECYANATION
Akira MIYASHITAYoshiyuki MATSUOKAAtsushi NUMATATakeo HIGASHINO
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1996 Volume 44 Issue 2 Pages 448-450

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Abstract

The anions derived form O-aroylmendelonitriles 1 reacted with Michael addition acceptors such as acrylonitrile (7) and methyl acrylate (10) to give the corresponding 1, 4-diketones 12, 13, and 15 in moderate to good yields. Under acidic conditions, the 1, 4-diketones 12, 13, and 15 were converted into the furans 17, 18 and 19 in good yields.

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© The Pharmaceutical Society of Japan
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