A NOVEL CARBON-CARBON BOND FORMATION AT THE C4 POSITION OF β-LACTAMS. FLUORIDE ION INDUCED DESILYLATIVE α-HYDROXYALKYLATION OF 3-ALKYLIDENE-4-TRIMETHYLAZETIDIN-2-ONES WITH ALDEHYDES

Katsumi HOTODA; Mitsuaki AOYAGI; Toshikatsu TAKANAMI; Kohji SUDA

doi:10.1248/cpb.44.466

Katsumi HOTODA, Mitsuaki AOYAGI, Toshikatsu TAKANAMI, Kohji SUDA

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Keywords: β-lactam, desilylative α-hydroxyalkylation, 3-alkylidene-4-trimethylsilylazetidin-2-one, 3-alkylidene-4-(α-hydroxy)-alkylazetidin-2-one, aldehyde, fluoride ion

JOURNAL FREE ACCESS

1996 Volume 44 Issue 2 Pages 466-468

DOI https://doi.org/10.1248/cpb.44.466

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Abstract

the reaction of 3-alkylidene-4-trimethylsilylazetidin-2-ones with aldehydes in the presence of fluoride ion gave 3-alkylidene-4-(α-hydroxy)-alkylazetidin-2-ones in good to moderate yields.

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