Preparation of Optically Active 2-(Trifluoromethyl)alkan-1-ols by Catalytic Asymmetric Hydrogenation

Katsuhiko ISEKI; Yoshichika KUROKI; Takabumi NAGAI; Yoshiro KOBAYASHI

doi:10.1248/cpb.44.477

Katsuhiko ISEKI, Yoshichika KUROKI, Takabumi NAGAI, Yoshiro KOBAYASHI

著者情報

キーワード: asymmetric hydrogenation, asymmetric synthesis, chiral fluorinated compound, 2-(trifluoromethyl)alkan-1-ol, 2, 2'-bis(diphenylphosphino)-1, 1'-binaphythyl

ジャーナルフリー

1996 年 44 巻 3 号 p. 477-480

DOI https://doi.org/10.1248/cpb.44.477

詳細

抄録

The hydrogenation of (E)-2-(trifluoromethyl)alk-2-en-1-ols catalyzed by Ru-2, 2'-bis(diphynylphosphino)-1, 1'-binaphthyl (Ru-BINAP) and Rh-BINAP was carried out with good enantiomeric excess (71-83% ee). Ru-BINAP-catalyzed hydrogenation converted 2-(trifluoromethyl)acrylic acid to the corresponding saturated acid whose esterification and reduction provided optically active 2-(trifluoromethyl)propan-1-ol in 80% ee.

責任著者(Corresponding author)

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