Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Chiral Pyrrolidine Derivatives as Catalysts for the Enantioselective Addition of Diethylzinc to Aldehydes
Nobuo IKOTA, Hiroko INABA
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Keywords: asymmetric addition, chral hydroxylated pyrrolidine, D-ribonolactone, chiral catalyst ligand, diethylizinc, optically active secondary alcohol
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1996 Volume 44 Issue 3 Pages 587-589

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Abstract
A chiral hydroxylated pyrrolidine derivative (4) and an N-(2-mercaptoethyl)pyrrolidine derivative (1c) were synthesized from D-ribonolactone and were used as chiral catalyst ligands in the reaction of diethylzinc and aldehydes. High asymmetric induction of up to 95% ee was observed in the addition to aromatic aldehydes using the chiral hydroxylated pyrrolidine derivative 4.
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© The Pharmaceutical Society of Japan
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