Synthesis of the Interferon-α Inducer Imiquimod by Thermal Electrocyclic Reactions of 1- and 2-Azahexatriene Systems

Haruyuki YOSHIOKA; Yuhji MATSUYA; Tominari CHOSHI; Eiichi SUGINO; Satoshi HIBINO

doi:10.1248/cpb.44.709

Haruyuki YOSHIOKA, Yuhji MATSUYA, Tominari CHOSHI, Eiichi SUGINO, Satoshi HIBINO

Author information

Keywords: imiquimod, thermal electocyclic reaction, azahexatriene system, imidazo[4, 5-c]quinoline, synthesis

JOURNAL FREE ACCESS

1996 Volume 44 Issue 4 Pages 709-714

DOI https://doi.org/10.1248/cpb.44.709

Details

Abstract

The interferon-α inducer imiquimod (1), possessing an imidazo[4, 5-c]quinoline ring, has been newly synthesized by two routes based on thermal electrocyclic reactions of 1- and 2-azahexatriene systems inovlving the imidazole 4, 5-bond.

Corresponding author

Register with J-STAGE for free!