Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
NOVEL PREPARATION OF FREE FLOWING SPHERICALLY GRANULATED DIBASIC CALCIUM PHOSPHATE ANHYDROUS FOR DIRECT TABLETTING
Kiyoshi TAKAMIHitoshi MACHMURAKenemasa TAKADOMichiji INAGAKIYoshiaki KAWASHIMA
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JOURNAL FREE ACCESS

1996 Volume 44 Issue 4 Pages 868-870

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Abstract
Free flowing spherically granulated (average diameter, 70 or 115 μm) dibasic calcium phosphate anhydrous (DCPA) for direct tabletting was prepared by a restricted crystal growing synthesis of DCPA, followed by spray drying of its aqueous dispersions. The spherically granulated DCPA had larger specific suraface area (32 to 34 m2/g), because they had porous structures compoesd of very fine primary crystals (Heywood diameter, 0.1-1.0 μm) compared to conventionally prepared DCPA (Heywood diameter, 2.0-5.0 μm). The crystallinity of granulated DCPA was lower than that of conventional DCPA. Those micromeritic characteristics of granulated DCPA might correlated closely with their dramatically improved tablettability.
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© The Pharmaceutical Society of Japan
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