Heterocyclic Analogues of Quinone Methide : Preparation and Cytotoxicity of 3-Oxo-3H-pyrazolo[1, 5-a]indole Derivatives

Hajime KATAYAMA; Naoyuki TAGAWA; Yusuke KAWADA; Keiichi SHIOBARA; Kimiyoshi KANEKO; Yurie HONDA; Noriko KONDO; Yoshiaki IKEDA

doi:10.1248/cpb.45.143

Hajime KATAYAMA, Naoyuki TAGAWA, Yusuke KAWADA, Keiichi SHIOBARA, Kimiyoshi KANEKO, Yurie HONDA, Noriko KONDO, Yoshiaki IKEDA

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Keywords: quinone methide heterocyclic analogue, preparation, UV-VIS spectrum, NMR spectrum, cytotoxicity, 3-oxo-3H-pyrazolo[1, 5-a]indole derivative

JOURNAL FREE ACCESS

1997 Volume 45 Issue 1 Pages 143-147

DOI https://doi.org/10.1248/cpb.45.143

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Abstract

A series of 3-oxo-3H-pyrazolo[1, 5-a]indole derivatives was prepared and characterized as heterocyclic analogues of quinone methide. These compounds showed some cytotoxicity to cancer cells, but were ineffective in an in vivo test against murine leukemia L1210.

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