IDENTIFICATION OF MAJOR PIGMENTS CONTAINING D-AMINO ACID UNITS IN COMMERCIAL MONASCUS PIGMENTS

Kyoko SATO; Yukihiro GODA; Shiho SAKAMOTO Sasaki; Hiroshi SHIBATA; Tamio MAITANI; Takashi YAMADA

doi:10.1248/cpb.45.227

Kyoko SATO, Yukihiro GODA, Shiho SAKAMOTO Sasaki, Hiroshi SHIBATA, Tamio MAITANI, Takashi YAMADA

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Keywords: monascorubrin, rubropunctatin, L- and D-alanine, L- and D-aspartic acid, Monascus

JOURNAL FREE ACCESS

1997 Volume 45 Issue 1 Pages 227-229

DOI https://doi.org/10.1248/cpb.45.227

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Abstract

Eight major pigments have been isolated from commercial Monascus pigments. The structural data on the pigments were obtained using NMR, MS, and semisyntheses. The pigments were characterized as alanine or aspartate derivatives of the orange pigments of Monascus, monascorubrin (1) and rubropunctatin (2), which have an azaphilone structure. The semisyntheses revealed that the amino acid units of the isolated compounds were the D-forms as well as the L-forms.

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