Antitumor Agents. 168. Dysoxylum cumingianum. IV. The Structures of Cumingianosides G-O, New Triterpene Glucosides with a 14, 18-Cycloapotirucallane-Type Skeleton from Dysoxylum cumingianum, and Their Cytotoxicity against Human Cancer Cell Lines

Abstract

Nine new triterpene glucosides, named cumingianosides G-O (4-7, 9, 12-15), containing a 14, 18-cycloapotirucallane-type skeleton were isolated from a cytotoxic fraction of the leaves of Dysoxylum cumingianum. The structures of the new compounds were established on the basis of chemical and spectral examinations. Evaluation of the cytotoxic activity of cumingianosides G-O showed that cumingianoside M exhibited significant (<4 μM) cytotoxicity, especially against leukemia and melanoma cell lines.