Radical Cyclization in Heterocycle Synthesis. II. Total Synthesis of (±)-Anantine and (±)-Isoanatine

Takeaki NAITO; Yuko HONDA; Vanida BHAVAKUL; Sayaka YAMAGUCHI; Azusa FUJIWARA; Okiko MIYATA; Ichiya NINOMIYA

doi:10.1248/cpb.45.1932

Takeaki NAITO, Yuko HONDA, Vanida BHAVAKUL, Sayaka YAMAGUCHI, Azusa FUJIWARA, Okiko MIYATA, Ichiya NINOMIYA

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Keywords: anantine, imidazole alkaloid, radical cyclization, sulfur, selenium, total synthesis

JOURNAL FREE ACCESS

1997 Volume 45 Issue 12 Pages 1932-1939

DOI https://doi.org/10.1248/cpb.45.1932

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Abstract

(±)-Anantine, (±)-isoanatine and related compounds were synthesized via two key reactions, sulfanyl radical addition-cyclization and stereoselective construction of the E-benzylidene moiety.

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