Synthese and Antifungal Activity of dl-Griseofulvin and Its Congeners. III

Yasuo TAKEUCHI; Ikuo WATANABE; Keiji MISUMI; Mari IRIE; Yoko HIROSE; Kazumi HIRATA; Masatoshi YAMATO; Takashi HARAYAMA

doi:10.1248/cpb.45.2011

Yasuo TAKEUCHI, Ikuo WATANABE, Keiji MISUMI, Mari IRIE, Yoko HIROSE, Kazumi HIRATA, Masatoshi YAMATO, Takashi HARAYAMA

著者情報

キーワード: griseofulvin, thiogriseofulvin, 3(2H)-benzofuranone, antifungal activity

ジャーナルフリー

1997 年 45 巻 12 号 p. 2011-2015

DOI https://doi.org/10.1248/cpb.45.2011

詳細

抄録

Several congeners (1b-g), with novel substituents on the benzene ring of griseofulvin, were prepared by the application of a synthetic method developed by us. Antifungal activity of these congeners decreased in order of dl-griseofulvin (1a)=1d>1b, c»1e-f (inactive). The relationship between the antifungal activity and the position or kind of substituents on the benzene ring of griseofulvin is discussed.

責任著者(Corresponding author)

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