An Amphiphile-Lipase Aggregate Bearing 1, 2-Dialkylated Mannitol Ether as a New Type of Immobilized Enzyme in Organic Solvents

Hiroyuki AKITA; Keisuke KATO; Isao UMEZAWA; Hiroko MATSUKURA

doi:10.1248/cpb.45.2085

Hiroyuki AKITA, Keisuke KATO, Isao UMEZAWA, Hiroko MATSUKURA

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Keywords: enantioselective acetylation, enantioselective hydrolysis, α-acetoxy ester, thioindolmycin, amphiphile-lipase aggregate

JOURNAL FREE ACCESS

1997 Volume 45 Issue 12 Pages 2085-2088

DOI https://doi.org/10.1248/cpb.45.2085

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Abstract

Neutral amphiphiles of a new type corresponding to 1, 2-dialkylated mannitol ethers (6-10) were synthesized. Amephiphile-lipase aggregates were found to function as an immobilized enzyme system for enantioselective acetylation or enantioselective hydrolysis of α-hydroxy esters or α-acetoxy esters, respectively, in organic solvents.

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