A New Method to Modify the C-4 Position of 10-Deacetylbaccation III

Kouichi UOTO; Haruhiro TAKENOSHITA; Takashi ISHIYAMA; Hirofumi TERASAWA; Tsunehiko SOGA

doi:10.1248/cpb.45.2093

Kouichi UOTO, Haruhiro TAKENOSHITA, Takashi ISHIYAMA, Hirofumi TERASAWA, Tsunehiko SOGA

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Keywords: paclitaxel, taxoid, 10-deacetylbaccatin III, C-4 acetyl group, alkylation, anion

JOURNAL FREE ACCESS

1997 Volume 45 Issue 12 Pages 2093-2095

DOI https://doi.org/10.1248/cpb.45.2093

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Abstract

We have developed a new method to modify the C-4 position of 10-deacetylbaccatin III (5) using the C-4 acetoxy anion of the 13-keto derivative (7) and various alkyl halides. The method developed herein shound be very useful for the preparation of C-4 modified taxoid analogs.

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