DEPURINATION OF ADENOSINE AND DEOXYADENOSINE MONOPHOSPHATES IN THE HEMIN-HYDROPEROXIDE SYSTEM

Tadayuki UNO; Mayumi TSUJI; Mika SHOJI; Michiyo SHIKISHIMA; Saburo SHIMABAYASHI; Toshiharu TANAKA; Mitsuru IRIKURA

doi:10.1248/cpb.45.2110

Tadayuki UNO, Mayumi TSUJI, Mika SHOJI, Michiyo SHIKISHIMA, Saburo SHIMABAYASHI, Toshiharu TANAKA, Mitsuru IRIKURA

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Keywords: hemin, adenine, peroxide, oxidation, cleavage, HPLC

JOURNAL FREE ACCESS

1997 Volume 45 Issue 12 Pages 2110-2112

DOI https://doi.org/10.1248/cpb.45.2110

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Abstract

The adenine base was liberated by the oxidative cleavage of the N-glycosidic bond of substrates (5'- and 3'-AMP, 5'- and 3'-dAMP) in the hemin-cumene hydroperoxide system, which was accelerated in the presence of 1-methylimidazole.

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