Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Effect of the Basidiomycete Poria cocos on Experimental Dermatitis and Other Inflammatory Conditions
Maria Jesus CUELLARRosa Maria GINERMaria del Carmen RECIOMaria Jose JUSTSalvador MANEZJose Luis RIOS
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1997 Volume 45 Issue 3 Pages 492-494

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Abstract

The hydroalcoholic extract from P. cocos was examined for oral and topical anti-inflammatory activities. It proved to be active against carrageenan, arachidonic acid, tetradecanoyl phorbol acetate (TPA) acute edemas, TPA chronic inflammation and oxazolone delayed hypersensitivity in mice. Two lanostane-type triterpenes were isolated and identified by spectroscopic methods as dehydrotumulosic and pachymic acids. Their ID50 on acute TPA edema was 4.7×10-3 and 6.8×10-4 μmol/ear, respectively.

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© The Pharmaceutical Society of Japan
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