Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Studies on the Constituents of Broussonetia Species. I. Two New Pyrrolidine Alkaloids, Broussonetines C and D, as β-Galactosidase and β-Mannosidase Inhibitors from Broussonetia kazinoki SIEB.
Makio SHIBANOSatoshi KITAGAWAGenjiro KUSANO
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1997 Volume 45 Issue 3 Pages 505-508

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Abstract
Two new pyrrolidine alkaloids called broussonetines C and D were isolated from the branch of Broussonetia kazinoki SIEB. (Moraceae). Broussonetines C and D were formulated as (2R, 3R, 4R, 5R)-2-hydroxymethyl-3, 4-dihydroxy-5-(10-oxo-hydroxytridecyl)pyrrolidine (1) and (2R, 3R, 4R, 5R)-2-hydroxymethyl-3, 4-dihydroxy-5-(9-oxo-13-hydroxytridecyl)pyrrolidine (2), respectively, by spectroscopic and chemical methods. 1 and 2 showed an inhibition to β-galactosidase and β-mannosidase.
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© The Pharmaceutical Society of Japan
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