Synthesis of a New Phenol Glycoside, Neohancoside C from Cynanchum hancockianum

Yaeko KONDA; Yayoi IWASAKI; Shihomi TAKAHATA; Shiho ARIMA; Tsuneyuki TOIDA; Eisuke KAJI; Kazuyoshi TAKEDA; Yoshihiro HARIGAYA

doi:10.1248/cpb.45.626

Yaeko KONDA, Yayoi IWASAKI, Shihomi TAKAHATA, Shiho ARIMA, Tsuneyuki TOIDA, Eisuke KAJI, Kazuyoshi TAKEDA, Yoshihiro HARIGAYA

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Keywords: neohancoside C, synthesis, phenol glycoside, Cynanchum hancockianum, phase-transfer-catalyzed glycosidation

JOURNAL FREE ACCESS

1997 Volume 45 Issue 4 Pages 626-630

DOI https://doi.org/10.1248/cpb.45.626

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Abstract

Neohancoside C (1) is a new phenol glycoside isolated from Cynanchum hancockianum, which is a Chinese folk medicine having antitumor activity. The synthesis of 1, 2-acetylphenyl β-D-xylopyranosyl-(1→6)-β-D-glucopyranoside, was achieved by phase-transfer-catalyzed glycosidation using glycosyl bromide.

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