Synthesis and Hypolipidemic Activity of Diesters of Arylnaphthalene Lignan and Their Heteroaromatic Analogs
1997 Volume 45 Issue 4 Pages 678-684
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1997 Volume 45 Issue 4 Pages 678-684
A series of diesters of arylnaphthalene lignan and their heteroaromatic analogs were synthesized and evaluated for hypolipidemic activity. The diesters with modifications at C-3 showed excellent hypocholesterolemic and high-density lipoprotein (HDL) cholesterol-elevating activities. Structure-activity analysis indicated that the 2-pyridylmethyl ester 51 has the optimum activity.
